FloraTummys Probiotic is being used in preterm infants in the NICU. Most protocols include mixing one FloraTummys packet with 3ml of breastmilk or formula during feeding or NG Tube with normal saline. For list of hospitals and protocols contact firstname.lastname@example.org.
“…our NEC rate dropped from 14.6% to 3.4% during the six months of probiotic use.”
From a Clinical NICU Pharm, D. using FloraTummys Feb 28, 2017
The Cochrane Review: (24 NEC-Probiotic studies) The authors concluded:
“Enteral supplementation of probiotics prevents severe NEC and all cause mortality in preterm infants. Our updated review of available evidence strongly supports a change in practice. Head to head comparative studies are required to assess the most effective preparations, timing, and length of therapy to be utilized.”
“The administration of a mixture of probiotics (nine trials) significantly reduced the incidence of mortality (RR 0.62, 95% CI 0.47 to 0.81). The administration of Lactobacillus species alone (four trials), bifidobactirium species alone (two trials), or Saccharomycesboulardii alone (one trial) did not reduce mortality…”
2016 Pediatric Pharmacy Advocacy Group (PPAG) Probiotics-NEC Review. Recommendations were to use:
Results: “…The use of dual-strain probiotics significantly reduced the risk of NEC (HR = 0.48; 95% CI = 0.38-0.62), overall mortality (HR = 0.60, 95% CI = 0.44-0.83), mortality after NEC (HR = 0.51, 95% CI = 0.26-0.999) and nosocomial BSI (HR = 0.89, 95% CI = 0.81-0.98).
These effects were even more pronounced in the subgroup analysis of preterm infants with birth weights below 1,000 g.”
Denkel LA1, Schwab F1, Garten L2, Geffers C1, Gastmeier P1, Piening B1.Institute of Hygiene and Environmental Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.2 Dept. of Neonatology, Charité Universitätsmedizin Berlin, Berlin, Germany.
“NEC rate should be one of the first determinants when considering the use of probiotics for the prevention of NEC in the NICU.”
Sherry A. Luedtke, PharmD, Jacob T. Yang, PharmD, and Heather E. Wild, PharmD
Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, Texas